Drug | Targets | Z score |
---|---|---|
MG-132 | Proteasome, CAPN1 | -0.832581 |
POMHEX | -0.71128 | |
Bleomycin (50 uM) | dsDNA break induction | -0.633907 |
OSI-027 | MTORC1, MTORC2 | -0.572736 |
Refametinib | MEK1, MEK2 | -0.520324 |
Dasatinib | ABL, SRC, Ephrins, PDGFR, KIT | -0.51981 |
123829 | -0.456026 | |
Ulixertinib | ERK1, ERK2 | -0.441568 |
PRIMA-1MET | TP53 activation | -0.380933 |
UMI-77 | MCL1 | -0.346328 |
Methotrexate | Antimetabolite | -0.309973 |
Pictilisib | PI3K (class 1) | -0.253464 |
Selumetinib | MEK1, MEK2 | -0.253241 |
Linsitinib | IGF1R | -0.236792 |
PAK_5339 | PAK1, PAK2 | -0.199705 |
741909 | -0.184949 | |
PD0325901 | MEK1, MEK2 | -0.154041 |
Bleomycin | dsDNA break induction | -0.148825 |
Lapatinib | EGFR, ERBB2 | -0.148381 |
XAV939 | TNKS1, TNKS2 | -0.130918 |
Trametinib | MEK1, MEK2 | -0.101879 |
Pevonedistat | NAE | -0.0977012 |
SCH772984 | ERK1, ERK2 | -0.0897295 |
Dactolisib | PI3K (class 1), MTORC1, MTORC2 | -0.0826884 |
LMP744 | TOP1 | -0.0733461 |
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